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Metabolic dysfunction–associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a multifaceted disorder that involves hepatic fat accumulation and at least one of five cardiometabolic risk factors. In recent years, a line of evidence has suggested a close association between intestinal health and liver health. What is the connection between the gut microbiome and MASLD, and how can lifestyle-based therapies affect the clinical measures of this di
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Researchers at Mayo Clinic's Center for Individualized Medicine have made a groundbreaking discovery: a rare genetic variant that can directly cause metabolic dysfunction-associated steatotic liver disease, formerly known as nonalcoholic fatty liver disease. It is one of the most common diseases in the world. ⁠ ⁠ Until now, scientists believed the disease resulted from a combination of genetic and environmental factors. This study, published in Hepatology, reveals that in some cases, a single in
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