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This is because 0.3-0.5mg doses of melatonin will raise plasma concentrations of melatonin into the normal range. Also when your melatonin receptors are exposed to a higher dose they will become less responsive over time.If you take melatonin for sleep please discuss optimal dosing with your Doctor Research articles are available on pubmed.How much melatonin do you take? | Kunal Sood, MD
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