Imetelstat sodium works by blocking the activity of an enzyme called telomerase, which is found at high levels in cells that divide rapidly, including cancer cells. Blocking this enzyme keeps cancer cells …

Most cancers and neoplastic progenitor cells have elevated telomerase activity and preservation of telomeres that promote cellular immortality, making telomerase a rational target for the treatment of …

Jul 16, 2024 · Rytelo (imetelstat) is an injectable telomerase inhibitor that may be used to treat adults with low- to intermediate-1 risk myelodysplastic syndromes (MDS) with transfusion-dependent anemia.

Mar 18, 2025 · In June 2024, imetelstat (Rytelo™) became the first telomerase inhibitor approved by the U.S Food and Drug Administration (FDA). Imetelstat treats low- to intermediate-risk myelodysplastic …

Jun 16, 2024 · Imetelstat can cause liver toxicity, which your oncology care team may monitor for using blood tests called liver function tests. Notify your healthcare provider if you notice yellowing of the …

Imetelstat is a first-in-class, small-molecule, 13-mer oligonucleotide telomerase inhibitor. The imetelstat molecule has a sequence complementary to the ribonucleic acid (RNA) component of human …

RYTELO® (imetelstat) is indicated for treatment of adult patients with low- to intermediate-1 risk myelodysplastic syndromes (MDS) with transfusion-dependent anemia.

Imetelstat This information from Lexicomp ® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.

Imetelstat is FDA approved for the treatment of adult patients with low- to intermediate-1 risk myelodysplastic syndromes (MDS) with transfusion-dependent anemia requiring 4 or more red blood …

2 days ago · Geron's first-in-class cancer drug Rytelo, recently approved by the FDA for myelodysplastic syndromes (MDS), is priced three to four times higher than it should be, according to the Institute for ...