Gut

Hospitalisation in cirrhosis is linked to distinct gut microbiome structural and functional profiles: a multinational metagenomic study

Background Hospitalisations represent major clinical events in cirrhosis, yet prediction based on clinical variables alone remains limited. Objective Given the role of the gut microbiome in disease ...
Gut

A durably colonising engineered native symbiont enables sustained intestinal delivery for metabolic dysfunction and colitis

Background Engineered bacterial therapeutics represent a promising strategy for sustained intestinal delivery of therapeutic molecules, but their efficacy is limited by inefficient colonisation, ...
Gut

Coordinated cellular programmes distinguish responses to neoadjuvant PD-L1 blockade and potentiate combinatorial immunotherapy in ESCC

Background Programmed death ligand 1 (PD-L1) blockade offers new therapeutic options for oesophageal squamous cell carcinoma (ESCC); however, the underlying mechanisms and associated biomarkers that ...
Gut

Divergent microbial preludes to necrotising enterocolitis defined by gut phages and bacterial resistomes

Background Translating microbiome correlations into robust predictive features for complex gut disorders remains elusive, ...
Gut

Global epidemiology of disorders of gut–brain interaction: new insights with Rome V

Following publication of the Rome V diagnostic criteria for disorders of gut–brain interaction (DGBI) earlier this year,1 the findings of the updated global epidemiology survey of DGBI in this issue ...
gut.bmj

Multi-kingdom signatures of the gut microbiome in Lynch syndrome: a prospective model for colorectal cancer evolution

Recent work in Gut has highlighted multi-kingdom interactions between gut bacteria and bacteriophage (‘phage’) as contributors to Crohn’s disease.1 Whether similar alterations characterise colorectal ...
gut.bmj

Rare cause of epigastric distension and vomiting

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gut.bmj

Deferring first surveillance to 3 years after colorectal ESD is not supported by these data

Qatomah and colleagues conclude that the first surveillance colonoscopy (SC1) after colorectal endoscopic submucosal dissection (ESD) can safely be delayed to 3 years.1 We congratulate the authors on ...
gut.bmj

Proteomic resolution of the MASLD cardiometabolic spectrum identifies sex-driven endotypes and predicts systemic mortality

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous condition where overlapping cardiometabolic risk factors challenge accurate prognostic prediction.
gut.bmj

Galectin-14, a primate-specific oncofetal protein, impairs anti-tumour immunity in hepatocellular carcinoma by driving elevated heparan sulphate modification

Background The liver naturally exhibits robust glycosylation processes, yet how aberrant glycosylation affects hepatocellular carcinoma (HCC) and its underlying mechanisms remains poorly understood.
gut.bmj

A patient-driven agenda for liver cirrhosis research

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gut.bmj

Colonoscopy compliance matters more than time to colonoscopy after a positive FIT result

Our study of a national cohort showed no increased risk of colorectal cancer (CRC), advanced-stage CRC or advanced adenoma when colonoscopy was delayed for up to 24 months following a positive faecal ...