12 min read | Unique research highlights an overlooked mental health disparity among Indigenous North American people with HD – and the need for care grounded in trust, community partnership, and ...

HDBuzz has been following SKY-0515 since the first results from its Phase 1 study were announced in 2024. Early testing in ...

In plain language. Written by scientists. There’s more good news in the forecast in the Huntington’s disease therapeutic space as we receive positive results from Skyhawk Therapeutics about their ...

Long-time HDBuzz readers may recognise pridopidine. Pridopidine has had one of the longest and most winding development journeys of any experimental HD therapy. Originally developed as a treatment for ...

A new Phase 1 study is testing SRP-1005, a huntingtin-lowering therapy given by injection under the skin. It’s early days, but this approach could add an important new arrow to the HD drug development ...

First to speak was Aikaterini Papadopoulou, who talked about her work targeting a fragment of the expanded HTTHTT one abbreviation for the gene that causes Huntington’s disease. The same gene is also ...

This morning kicks off with talks focussed on HD genetics and how DNA repair machines influence how symptoms start and then progress in people with HD. The first speaker was Vanessa Wheeler, whose ...

This week, HDBuzz is attending the HD2026 Milton Wexler Biennial Symposium in Boston, Massachusetts. Held every other year and organized by the Huntington’s Disease Foundation (HDF), this conference ...

Huntington’s disease (HD) is caused by a change in a single gene known as huntingtin. This gene contains the instructions for making the huntingtin proteinhuntingtin protein The protein produced by ...

Today, Roche announced in a community letter difficult news for the Huntington’s disease (HD) community, discontinuing two separate clinical programmes after new data emerged from ongoing studies. The ...

⏱️6 min read | PROTACs act like a precision pruning tool, trimming away toxic huntingtin protein while leaving the healthy form intact. In cells and HD mice, this targeted clean-up improved health and ...

A paper recently published in Nature Medicine caught our attention. In it, researchers celebrated Australia’s new federal law banning life insurance companies from using genetic test results when ...