Transcranial focused ultrasound (tFUS) can modulate activity in deep brain regions non-invasively, yet its effects remain variable and incompletely understood. Because sonication deposits mechanical ...

This important study shows that neural responses to visual input during active vision are more closely aligned with self-generated eye movements than with fixation onset. The evidence for neural ...

This study presents valuable findings regarding the role of the P2X7 receptor in retinoic acid signaling-mediated retinal remodeling following photoreceptor degeneration. However, the evidence ...

This important work considerably advances our understanding of the nature of ongoing thought across individuals and across task contexts. Using a combination of fMRI brain data and experience sampling ...

In cancer, tumor escape often arises following treatments. This is especially true during deprivation therapies, where this phenomenon has been linked to steroid signaling reactivation despite ...

Science is better when we publish according to our values! Most publishing models act as a barrier, rather than a medium, between authors and audiences; eLife feels like the opposite.

Mas-Related GPCR X4 (MRGPRX4) is a sensory neuron-restricted receptor for cholestatic itch. Here, we identify MRGPRX4 as an unexpected melanoma driver. MRGPRX4 is upregulated in melanoma and is ...

This is a valuable study that contributes to our understanding of transcriptomic responses in microglia to HIV infection in the human brain. The evidence provided remains incomplete, and further ...

To enable more rational optimization of MVA-based vaccines, we developed a mechanistic and executable systems vaccinology framework based on Boolean modeling to capture the dynamics of vaccine-induced ...

The authors highlight three potential regulators - galectin 1, galectin 3, and Myc - providing solid evidence for potential roles in modulating the proliferation of cochlear GER cells using gene ...

Behavioural diversity across fruit flies changes with individual learning, even when genetic, past and momentary environmental factors are held constant.

Human spatial representations are often assumed to represent Euclidean properties such as length, distance, and angle. Here we test an alternative (but not mutually exclusive) possibility – that ...