Omar Khan and Steelers brass were exhilarated to select Derrick Harmon 21st overall in the 2025 NFL Draft. With high expectations, the Oregon product showed out at training camp and in his preseason snaps, earning his spot as the team’s starting defensive end on Pittsburgh’s unofficial depth chart.

Coach Mike Tomlin said that Harmon is dealing with a knee sprain and categorized his timeline as "week-to-week" after the injury.

Pittsburgh Steelers first-round pick Derrick Harmon was carted off the field during Thursday's preseason game against the Carolina Panthers after sustaining a knee sprain. Harmon is expected to be out for about a month, according to NFL Media, which makes him a candidate to begin the season on injured reserve.