By degrading PNNs using the enzyme Chondroitinase ABC, the researchers were able to observe how damage to these structures impacted synapses and astrocytes, Interestingly, they found that synapses ...
Researchers at Kanazawa University have identified a previously unrecognized mechanism by which structural changes in the cerebellum influence social behavior. The study demonstrates that disruption ...
Perineuronal nets, rigid structures that hold certain neurons in place, affect a surprising amount of brain activity, including some associated with chronic pain. Neuroscientists, being interested in ...
Perineuronal nets (PNNs), a specialized extracellular matrix structures that surround the cell bodies and proximal dendrite of a subgroup of central nervous system neurons. Although known since 1893, ...
Specialized aggregations of extracellular matrix called perineuronal nets (PNNs) appear during juvenile stages of development and surround primarily fast-spiking, parvalbumin (PV)-containing GABAergic ...
中枢神经系统特定类型的神经元被包裹在细胞外基质蛋白复合物中，称为神经元周围网络（Perineuronal Nets, PNNs）。虽然已知PNNs通过调节突触可塑性来调控神经元活性，但其在精神疾病中的病理 ...
这篇综述深入探讨了神经元周围网络(PNNs)作为细胞外基质(ECM)特殊结构在神经可塑性调控中的核心作用。文章系统梳理了PNNs的分子组成（含CSPGs、HA等）、发育调控机制（涉及OTX2、SEMA3A等信号 ...
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