FDA approval targets NRG1 fusion–positive advanced cholangiocarcinoma, expanding biomarker-driven options beyond more common FGFR2 and IDH1 alterations. Zenocutuzumab delivered a 36.8% ORR in the ...

Noradrenaline transporter, also known as the norepinephrine transporter (NET), is a member of the monoamine transporters (MATs) family, which also includes the serotonin transporter (SERT) and ...

A study reported by researchers at NYU Langone Health’s Perlmutter Cancer Center and at the University of Oxford has offered up new insights into the workings of an immune cell surface receptor, ...

Angiogenesis, which plays a critical role in embryonic development and tissue repair, is controlled by a set of angiogenic signaling pathways. As a TF (transcription factor) belonging to the basic ...

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How can the hydrophobic effect drive binding between nonpolar protein interaction surfaces buried within the nonpolar regions of the membrane? Compared to bulk, the water concentration is at least a ...

A new study offers up yet more evidence that the endosome may be ground zero for Alzheimer’s disease pathogenesis. In Proceedings of the National Academy of Sciences on January 18, scientists led by ...

C99 is the immediate precursor for amyloid beta (Aβ) and therefore is a central intermediate in the pathway that is believed to result in Alzheimer’s disease (AD). It has been suggested that ...