Gut

Hospitalisation in cirrhosis is linked to distinct gut microbiome structural and functional profiles: a multinational metagenomic study

Background Hospitalisations represent major clinical events in cirrhosis, yet prediction based on clinical variables alone ...
Gut

Eosinophilic gastritis: burden of disease, diagnostic challenges and unmet needs

Eosinophilic gastritis (EoG) is a rare, chronic disease characterised by pathological eosinophilia of the stomach and ...
Gut

Global epidemiology of disorders of gut–brain interaction: new insights with Rome V

Following publication of the Rome V diagnostic criteria for disorders of gut–brain interaction (DGBI) earlier this year,1 the ...
Gut

Divergent microbial preludes to necrotising enterocolitis defined by gut phages and bacterial resistomes

Background Translating microbiome correlations into robust predictive features for complex gut disorders remains elusive, ...
Gut

A durably colonising engineered native symbiont enables sustained intestinal delivery for metabolic dysfunction and colitis

Background Engineered bacterial therapeutics represent a promising strategy for sustained intestinal delivery of therapeutic ...
Gut

Coordinated cellular programmes distinguish responses to neoadjuvant PD-L1 blockade and potentiate combinatorial immunotherapy in ESCC

Background Programmed death ligand 1 (PD-L1) blockade offers new therapeutic options for oesophageal squamous cell carcinoma ...
gut.bmj

Cost-effectiveness of laparoscopic ileocaecal resection versus infliximab treatment of terminal ileitis in Crohn’s disease: the LIR!C Trial

Objective Evaluate the cost-effectiveness of laparoscopic ileocaecal resection compared with infliximab in patients with ileocaecal Crohn’s disease failing conventional therapy. Design A multicentre ...
gut.bmj

The window hypothesis: haemodynamic and non-haemodynamic effects of β-blockers improve survival of patients with cirrhosis during a window in the disease

1 Department of Gastroenterology, Hvidovre University Hospital, Faculty of Health Sciences, Copenhagen University, Hvidovre, Copenhagen, Denmark 2 Department of Internal Medicine, Copenhagen ...
gut.bmj

Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats

Department of Surgery, Duke University Medical Center and Veterans’ Administration Hospital, Durham, NC, USA Correspondence to: Dr C R Mantyh, Duke University Medical Center, Box 3117, Durham, NC ...
gut.bmj

Visceral hypersensitivity is associated with GI symptom severity in functional GI disorders: consistent findings from five different patient cohorts

2 Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA 3 Translational Research Center for Gastrointestinal ...
gut.bmj

Colorectal cancers soon after colonoscopy: a pooled multicohort analysis

1 Department of Veterans Affairs Medical Center, White River Junction, VT and Dartmouth Medical School & The Dartmouth Institute, Hanover, New Hampshire, USA 2 Department of Veterans Affairs Medical ...
gut.bmj

Standard endoscopy with random biopsies versus narrow band imaging targeted biopsies in Barrett's oesophagus: a prospective, international, randomised controlled trial

1 Division of Gastroenterology and Hepatology, Veterans Affairs Medical Center, Kansas City, Missouri, USA 2 Division of Gastroenterology and Hepatology, University of Kansas School of Medicine, ...