Transcranial focused ultrasound (tFUS) can modulate activity in deep brain regions non-invasively, yet its effects remain variable and incompletely understood. Because sonication deposits mechanical ...

This important study shows that neural responses to visual input during active vision are more closely aligned with self-generated eye movements than with fixation onset. The evidence for neural ...

This important work considerably advances our understanding of the nature of ongoing thought across individuals and across task contexts. Using a combination of fMRI brain data and experience sampling ...

eLife reviews research in which approaches from the physical sciences are used to provide insights into the properties of biological systems and processes. Learn more about what we review and sign up ...

In cancer, tumor escape often arises following treatments. This is especially true during deprivation therapies, where this phenomenon has been linked to steroid signaling reactivation despite ...

Science is better when we publish according to our values! Most publishing models act as a barrier, rather than a medium, between authors and audiences; eLife feels like the opposite.

This raises the issue of whether deliberate endosymbiont introductions could be used to decrease crop damage caused by insect pests. Here we investigate how transinfecting Rickettsiella viridis and ...

Mas-Related GPCR X4 (MRGPRX4) is a sensory neuron-restricted receptor for cholestatic itch. Here, we identify MRGPRX4 as an unexpected melanoma driver. MRGPRX4 is upregulated in melanoma and is ...

It came to our attention that the originally published figure 5 (panel C) contained a visualization error that may have been misleading. Specifically, while the x ...

This is a valuable study that contributes to our understanding of transcriptomic responses in microglia to HIV infection in the human brain. The evidence provided remains incomplete, and further ...

To enable more rational optimization of MVA-based vaccines, we developed a mechanistic and executable systems vaccinology framework based on Boolean modeling to capture the dynamics of vaccine-induced ...