These five players haven't lived up to expectations for the Buffalo Bills over the first two games of the season, but there's still time to improve.

The Buffalo Bills placed linebacker Kawika Mitchell on injured reserve Friday, ending the seven-year veteran's season two days after he hurt his foot in practice. "Unfortunately Kawika had a lot worse of a problem than we had anticipated,

The Buffalo Bills are near or at the top of power rankings from multiple national publications. Buffalo holds a 2-0 record after defeating the Detroit Lions 41-31 on Thursday Night Football. The Bills' offense is firing on all cylinders, while the defense made enough stops to help Buffalo preserve their victory.

It will be week 2 with Marcus Mariota under center in place of the injured Jayden Daniels. That should translate to a more efficient offense. The Commanders stay within the number IF Jacory Croskey-Merritt can take advantage of a Colts’ defense that has been unable to slow the run in their first two games.

Here are five storylines to watch for during the lead up to kickoff between the Bills and Chargers in Week 3.

The Buffalo Bills' 2026 rookie class hasn't had much of a role this season as top pick T.J. Parker hasn't played much.

The Chargers lost to the Las Vegas Raiders in Week 2, 26-14, thanks to a whopping six fumbles and two interceptions. Meanwhile, Josh Allen and the Bills blew up the Detroit Lions, 41-31. So far, no NFL analysts have picked the Chargers to win, though it's still early in the week. Buffalo is a 7-point favorite. The over/under is 50 points.

The Buffalo Bills will resume practice for their Week 3 game on Wednesday, and wide receiver DJ Moore's status will be of great interest.

Ravens Pro Bowler Zay Flowers (hamstring) missed Week 2 against the New Orleans Saints. Rookie starter Ja’Kobi Lane (wrist) is on the injured reserve after undergoing surgery following a Week 1 win over the Indianapolis Colts.