Nature

Dimerization of G-Protein Coupled Receptors

Protein-protein interactions govern a large number of biological processes. A number of cell surface and nuclear receptors mediate their actions via dimerization. While this has been well established, ...
Nature

Epidermal growth factor receptor dimerization monitored in live cells

We present a method for monitoring receptor dimerization at the membrane of live cells. Chimeric proteins containing the epidermal growth factor (EGF) receptor extracellular and transmembrane domains ...
Health And Pharma

FDA Approves Bizengri as First Targeted Therapy for NRG1 Fusion+ Cholangiocarcinoma

The FDA has approved zenocutuzumab-zbco (BIZENGRI) for adults with advanced, unresectable or metastatic NRG1 fusion-positive ...
Targeted Oncology

FDA Approves Zenocutuzumab for NRG1 Fusion–Positive Cholangiocarcinoma

FDA approval targets NRG1 fusion–positive advanced cholangiocarcinoma, expanding biomarker-driven options beyond more common FGFR2 and IDH1 alterations. Zenocutuzumab delivered a 36.8% ORR in the ...
eLife

Single-domain antibody inhibitors target the coiled coil arms of the Bacillus subtilis SMC complex

A screen using in vitro-selected synthetic nanobodies identified inhibitors of SMC protein function in bacterial cells, revealing a coiled coil region as a vital component of the chromosome-folding ...