A variety of mutations in lentiviral vector expression systems have been shown to generate a non-integrating phenotype. We studied a novel 12 base-pair U3-long terminal repeats (LTR) integrase (IN) ...
Epigenetic mechanisms associated with DNA methylation of cytosine residues at CpG dinucleotides have a central role in normal human development and disease (Baylin and Jones, 2011). Advancements in ...
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