Canine intervertebral disc disease (IVDD) constitutes one of the principal causes of spinal cord dysfunction in dogs, with significant impacts on mobility and overall quality of life. This ...

The intervertebral discs between the spinal vertebrae comprise a gel-like core, the nucleus pulposus (NP), encased by a tough, fibrous outer ring. The NP’s high water content allows it to act like a ...

Spinal stenosis occurs when the space inside the spinal canal becomes too narrow. When the spinal canal gets too small, the spinal cord or nerves within this space can become compressed. Some people ...

Cervical myelopathy is a condition that happens when the spinal cord in the neck is compressed or squeezed. There are many things that can cause this, but one of the most common is cervical ...

Degenerative cervical disc disease may present with symptoms of pain and stiffness in the neck, and pain, paraesthesia, numbness or weakness of the limbs. Conservative treatment options include rest, ...

As people get older, the intervertebral discs in their spine tend to deteriorate, some of which end up being surgically replaced with implants. A new patient-specific spinal model, however, could help ...

Karin Wuertz-Kozak described her lab test equipment as a gym for cells. Stretching and compressions tests using bioreactors—her lab equipment—can make a difference in understanding how cells respond ...

Low back pain is the most prevalent musculoskeletal condition worldwide and is closely tied to the progressive degeneration of intervertebral discs. Aging remains the strongest risk factor for this ...

Schematic diagram depicting the mechanism of the rigid matrix regulating cell glycolysis in degenerated NPCs. In degenerated NP tissue, MRTF-A was activated by increased matrix stiffness and ...

Symptomatic degenerative disc disease of the lumbar spine occurs when the intervertebral discs supporting the vertebrae lose their elasticity. This can cause partial disc prolapse, which may be ...