Week 1 of the NFL schedule begins with the 2025 NFL Kickoff Game between the Eagles (-7.5) and Cowboys on Thursday, September 4 and continues with Chiefs vs. Chargers (+3) on Friday from Brazil. A full Sunday schedule is capped off by Bills vs.

Find the best sports betting apps in the U.S. for 2025. Choose the best mobile app to bet with using our comprehensive guide. Read now to learn more about the top betting apps.

An NFL player can’t bet on the NFL using a typical sportsbook, nor can they bet on it using a federally regulated prediction market.

NFL power rankings before NFL Week 1 games rank every team by Super Bowl odds, with Eagles, Ravens, Bills, Chiefs, Lions, Bengals, Rams, 49ers on top.

SportsLine's model reveals its top Week 1 college football picks and CFB predictions at major sports betting sites

In absence of full player prop menus, some top sports betting sites are offering player specials on marquee names in NFL preseason contests.

Arch Manning and No. 1 Texas football travel to No. 3 Ohio State Saturday. Read the American-Statesman staffs predictions and game preview.