Motor neurons innervate muscle cells to control various voluntary and involuntary movements. The progressive degeneration of motor neurons is the core of neuromuscular disorders, such as ALS. AxoCells ...

Motor neurons are some of the largest cells in the human body. In particular, upper neurons—extending from the cerebral cortex to the brain stem or spinal cord—average 60μm in diameter. 3,4 These ...

Despite the pivotal role of motor neurons in movement, how a single motor neuron contributes to control during movement remains unclear. Measuring the activity of individual neurons in moving animals ...

The kinesin-2 motor protein uses a hook-like adaptor and cargo-binding (HAC) domain to recognize and transport cargo along microtubule highways, revealing a cellular logistics system critical for ...

Human induced pluripotent stem cell (iPSC)-derived motor neurons (in green) co-cultured with iPSC-derived astrocytes (in red). [VIB] Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s ...

Converting one type of cell to another - for example, a skin cell to a neuron - can be done through a process that requires ...

A new pharmacological inhibitor can intervene in a central cell death mechanism that is responsible for the death of motor neurons and hence important for the progression of the motor neuron disease ...

CAMBRIDGE, MA -- Converting one type of cell to another — for example, a skin cell to a neuron — can be done through a process that requires the skin cell to be induced into a “pluripotent” stem cell, ...

For decades, scientists have known that motor proteins like kinesin-2 ferry vital cargo along microtubule "highways" inside cells. But how these molecular vehicles identify and bind to the right cargo ...