Tissue-specific antigens are expressed in the thymic medulla under the influence of the AIRE gene, suggesting that unresponsiveness to these peripheral antigens is a result of central tolerance. New ...

The deletion of self-reactive T cells during thymocyte development (a process termed central tolerance) is thought to be mediated mainly by medullary thymic epithelial cells (mTECs) and dendritic ...

The thymus is the organ in which T cells*1) differentiate. T cells express various T cell receptors for reacting with various pathogenic microbes and viruses. However, the thymus generates ...

Scientists from the Institute of Molecular Genetics of the Czech Academy of Sciences, in collaboration with the Faculty of Science at Charles University, have uncovered a completely new role for the ...