Tissue-specific antigens are expressed in the thymic medulla under the influence of the AIRE gene, suggesting that unresponsiveness to these peripheral antigens is a result of central tolerance. New ...
The thymus is the organ in which T cells*1) differentiate. T cells express various T cell receptors for reacting with various pathogenic microbes and viruses. However, the thymus generates ...
The deletion of self-reactive T cells during thymocyte development (a process termed central tolerance) is thought to be mediated mainly by medullary thymic epithelial cells (mTECs) and dendritic ...
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