The Chicago Cubs and the Minnesota Twins wrap up a 3-game interleague series Thursday at Target Field in Minneapolis.

When interleague play was introduced in 1997, it was a cool idea. It had its critics, to be sure, but a lot of people saw it as a fun, little novelty that was, at the very least, something new ...

When interleague play began in 1997, the only interaction between the two leagues since the creation of the American League in 1901 had been the World Series (created in 1903), the All-Star Game ...

Interleague play is now so ingrained in the baseball landscape, you couldn't uproot it with an earthquake. Jayson Stark is a senior writer for ESPN.com. Click here to send Jayson a question for ...

Interleague play, like many of the changes made on Bud Selig's watch, is defined by the unintended consequences left in its wake -- in this case, serious damage. Joe Sheehan | May 21, 2010.

Interleague play began in 1997 with each team playing 16 games against opponents in the opposite league. This is the third year each team plays 46 interleague games. Using Cleveland as an example ...

This coming Friday marks for some the first of 18 dates to circle on the baseball calendar, the first of 18 blemishes for others, as interleague play begins its 12th season. Equal parts, or ...

An eighth-inning go-ahead RBI single from Karter Weber powered the Parkston Mudcats to the victory on Tuesday night. Parkston downed the Lesterville Broncs 5-4 on the road in an interleague game, ...

The Chicago White Sox and the LA Dodgers play the second contest of a 3-game interleague series at Dodger Stadium Wednesday.

Interleague play began in 1997 with each team playing 16 games against opponents in the opposite league. This is the third year each team plays 46 interleague games.